Abstract: The study explores the potential neuroprotective role of citral, a monoterpenoid compound, in haloperidol-induced catalepsy, a common side effect of neuroleptic medications. Haloperidol, an antipsychotic drug, often induces extrapyramidal symptoms (EPS), including catalepsy, due to dopaminergic blockade. Citral, derived from plants like lemongrass, has been recognized for its anti-inflammatory, antioxidant, and neuroprotective properties, which may counteract these side effects. The study investigates the modulation of GABAergic and serotonergic neurotransmission by citral as a potential mechanism to reduce haloperidol-induced motor impairments.